Single Daily Dose of Aminoglycosides in the Treatment of Continuous Ambulatory Peritoneal Dialysis Peritonitis

Abstract

Toxicity of amlnoglycosides is a major concern in the treatment of continuous ambulatory peritoneal dialysis (CAPO) peritonitis. The relatively high blood levels and prolonged and repeated usage may all be contributory. The recognition of the so-called postantibiotic effect, together with the Increased phagocytosis of antiblotictreated cells, may introduce a new mode of therapy with once-dally dosage. Intermittent therapy with vancomycin Is already generally accepted. The extension of this modality to antibiotic therapy is discussed.