Biofilm and Foreign Body Infection the Significance to Capd-Associated Peritonitis

Author:

Holmes Clifford J.1,Evans Rosemary1

Affiliation:

1. From the Department of Microbiology, Travenol Laboratories, Round Lake, Illinois.

Abstract

Microbial colonization of indwelling and implantable medical devices and prostheses is known to precede the formation of an adherent biofilm, such as is found on peritoneal catheters during CAPD. Micro-organismderived exopolysaccharides within the biofilm matrix seem to confer unique biological properties on this material, such as enhanced resistance to host defenses and antimicrobial agents. It has been proposed that an adherent biofilm is a major contributing factor in the development of foreign-body infections, including CAPD peritonitis. The source of organisms which lead to biofilm formation on peritoneal catheters is unknown but may include “seeding” at the time of surgical placement and migration from the subcutaneous tunnel via the inner cuff.Strategies to inhibit biofilm development in industrial systems usually involve physical destruction of the biofilm and the use of biocides. Clinical success has been achieved by antimicrobial agents impregnated into or coated onto susceptible devices. Microbial adhesion to inanimate surfaces is a complex and multifaceted event. Continued research in this area, however, should increase our understanding of the factors involved underlying foreignbody infection.

Publisher

SAGE Publications

Subject

Nephrology,General Medicine

Cited by 24 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3