A Cross Sectional Assessment of Serum Vitamin O ANO Trigl Ycerioe Concentrations in a CAPO Population

Abstract

A cross sectional analysis of 41 patients on continuous ambulatory peritoneal dialysis (CAPD) for six to 54 months (mean, 21.7) showed that 58.5% and 19.5% had low levels of 1,25-(OH)2 vitamin D and 25-OH vitamin D respectively. C-terminal and N-terminal parathyroid hormone (PTH) levels were elevated in 85 and 75%, respectively. N-terminal PTH correlated (r -0.31, p < 0.05) with serum inorganic phosphorus, but not with vitamin D levels. Triglyceride and cholesterol concentrations were elevated in 76% and 19%; HDL cholesterol was low in 37%. Except for PTH levels, none of the other above measurements correlated with time on CAPD. The findings suggest that most CAPD patients have low 1,25(OH)2 vitamin D and elevated PTH and triglyceride serum concentrations. More study should be made concerning the clinical significance of and proper therapeutic interventions in these circumstances. Reduced serum concentrations of vitamin D metabolities and increased serum triglyceride concentrations have been described frequently in patients on continuous ambulatory peritoneal dialysis (CAPD) (1–4). In 41 patients in our CAPD program, we did a cross-sectional assessment of vitamin D and triglyceride levels to quantitate the frequency and severity of these problems. We correlated serum levels of vitamin D and triglyceride with time on CAPD and other variables.