Functional Characteristics of Peritoneal Macrophages of Renal Failure Patients on Peritoneal Dialysis

Author:

Sulowicz Wladyslaw1,Hanicki Zygmunt1,Chichocki Tadeusz2,Zembala Marek3,Ruggiero Irena3,Uracz Wojciech3

Affiliation:

1. Department of Nephrology, Nicolaus Copernicus University School of Medicine, Cracow, Poland

2. Department of Histology, Nicolaus Copernicus University School of Medicine, Cracow, Poland

3. Department of ClinicalImmunology, Nicolaus Copernicus University School of Medicine, Cracow, Poland

Abstract

Functional activity of peritoneal macrophages of 50 patients with end-stage renal failure on intermittent peritoneal dialysis (IPD) and of 30 control subjects with normal renal function was determined. Phagocytosis of latex particles by macrophages of dialyzed patients was significantly lower as compared with the controls. Further depression of the phagocytic activity was observed during bacterial peritonitis. Macrophages from the dialyzed patients also showed nonsignificantly decreased functional expression of Fc receptors (FcR) and increased spontaneous nitro blue tetrazolium (NeT) reduction.

Publisher

SAGE Publications

Subject

Nephrology,General Medicine

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