Effects of Sulodexide on Hemostatic Factors, Lipid Profile, and Inflammation in Chronic Peritoneal Dialysis Patients-Reference-Cited by-同舟云学术

Effects of Sulodexide on Hemostatic Factors, Lipid Profile, and Inflammation in Chronic Peritoneal Dialysis Patients

Published:2007-07 Issue:4 Volume:27 Page:456-460
ISSN:0896-8608
Container-title:Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
language:en
Short-container-title:Perit Dial Int

Author:

Kim Soon Bae¹,Kim Su Hee²,Lee Moo Song³,Chang Jai Won¹,Lee Sang Koo¹,Park Jung Sik¹

Affiliation:

1. Division of Nephrology Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine, Seoul

2. Division of Nephrology Department of Internal Medicine GangNeung Asan Hospital University of Ulsan College of Medicine, GangNeung

3. Department of Preventive Medicine University of Ulsan College of Medicine, Seoul, Korea

Abstract

Sulodexide, a standardized extractive glycosaminoglycan containing 80% “fast moving” heparin and 20% dermatan sulfate, decreased plasma D-dimer, a marker of intravascular coagulation, and fibrinogen levels in chronic peritoneal dialysis patients. Blood levels of von Willebrand factor, lipid, and high-sensitivity C-reactive protein were not significantly changed. No bleeding episodes were reported. These results suggest that sulodexide was effective in partially reversing the thrombogenic coagulation profile without increasing the risk of bleeding.

Publisher

SAGE Publications

Subject

Nephrology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/089686080702700415

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