Tenckhoff Catheter Replacement or Intraperitoneal Urokinase: A Randomised Trial in the Management of Recurrent Continuous Ambulatory Peritoneal Dialysis (CAPD) Peritonitis

Author:

Williams Anthony J.1,Boletis Loannis1,Johnson Brian F.1,Raftery Andrew T.1,Cohen Geoffrey L.1,Moorhead Peter J.1,Nahas A. Meguid El1,Brown Colin B.1

Affiliation:

1. Sheffield Regional Renal Unit, Royal Hallamshire and Northern General Hospitals, Sheffield

Abstract

A randomised trial, comparing Tenckhoff catheter replacement as a one-stage procedure and i.p. urokinase, was undertaken in the management of recurrent continuous ambulatory peritoneal dialysis (CAPD) peritonitis. In addition to appropriate i.p. antibiotic treatment, 17 patients received i.p. urokinase (5000 i.u.) on the second and fourth days of antibiotic treatment, and 14 patients underwent CAPD catheter replacement. An additional six patients also underwent catheter replacement following the recurrence of peritonitis after urokinase treatment. The subsequent recurrence rate of peritonitis following CAPD catheter replacement (5%) was significantly less than after urokinase (41%) ( p < 0.001). Fourteen patients remained free of peritonitis for at least three months after catheter replacement, and five patients were peritonitis-free following urokinase for this period.

Publisher

SAGE Publications

Subject

Nephrology,General Medicine

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