Intraperitoneal Administration of Recombinant Human Erythropoietin in Uremic Animals-Reference-Cited by-同舟云学术

Intraperitoneal Administration of Recombinant Human Erythropoietin in Uremic Animals

Published:1988-10 Issue:4 Volume:8 Page:249-252
ISSN:0896-8608
Container-title:Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
language:en
Short-container-title:Perit Dial Int

Author:

Bargman Joanne M.¹,Breborowicz Andre²,Rodela Helen¹,Sombolos Kostas¹,Oreopoulos Dimitrios G.¹

Affiliation:

1. Toronto Western Hospital, Toronto, Ontario, Canada

2. National Kidney Foundation of Canada.

Abstract

Previous protocols of administration of recombinant human erythropoietin to patients with end-stage renal disease have been by the i.v. route. Because this method would be impractical for the continuous ambulatory peritoneal dialysis patient, we designed an i.p. dosing protocol in uremic rabbits to examine whether significant amounts of this hormone could be absorbed from the peritoneal cavity. Our results demonstrate that almost all of the erythropoietin is absorbed (or adsorbed) during a prolonged dwell when administered undiluted by dialysate.

Publisher

SAGE Publications

Subject

Nephrology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/089686088800800404

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1. Pharmacological alterations of peritoneal transport rates and pharmacokinetics in peritoneal dialysis;Textbook of Peritoneal Dialysis;2000

2. Pharmacokinetics of intraperitoneal epoetin alfa in patients on peritoneal dialysis using an 8-hour “dry dwell” dosing technique;American Journal of Kidney Diseases;1999-10

3. Pharmacokinetics of recombinant human erythropoietin in children treated with continuous ambulatory peritoneal dialysis;European Journal of Pediatrics;1994-11

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