Re-Evaluation of Solute Transport Groups Using the Peritoneal Equilibration Test

Author:

Rodby Roger A.1,Firanek Catherine A.1,Sarpolis Ann L.1

Affiliation:

1. Rush Medical College, Chicago, Illinois, U.S.A.

Abstract

Objective To determine if the previously described peritoneal equilibration test (PET)-determined solute transport groups, as defined by Twardowski, fit our patient population. Design We reviewed the 195 initial standardized PETs (on 195 patients) performed through our peritoneal dialysis program since 1989. Using the method originally defined by Twardowski using the means and standard deviations of the PET-determined dialysis/plasma ratio (D/P) of creatinine and dialysate-to-0 hour dialysate (D/D0) glucose values, transport groupings for our patient population were determined. Comparisons were then made between patient populations. Results The mean 4-hour D/P creatinine in our patients was 0.70 ± 0.10. This compares to a mean of 0.65 ± 0.15 as determined by Twardowski, and indicates that our patients have higher mean solute transport characteristics and tighter ranges within transport groups than previously reported. Only 2% of our patients fell into the previously described low (L) range, with 30% low average (LA), 51% high average (HA), and 17% high (H). Using our data, we would redefine the groups by a 4-hour D/P creatinine as L < 0.60, LA = 0.60 – 0.70, HA = 0.70 – 0.80, and HA > 0.80. Using these values, our population fits a Gaussian distribution with 17% L, 31% LA, 33% HA, and 19% H. Conclusion Our patients have higher mean solute transport and tighter ranges within transport groups than previously reported. Using the previously defined PET-determined transport groupings, low transporters are particularly underestimated. If our population data are representative of the peritoneal dialysis population as a whole, these ranges should be redefined.

Publisher

SAGE Publications

Subject

Nephrology,General Medicine

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Peritoneal equilibration testing: Your questions answered;Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis;2022-11-09

2. The importance of ultrasonographic measurement of peritoneal wall thickness in pediatric chronic peritoneal dialysis patients;Renal Failure;2015-01-16

3. Techniques in Peritoneal Dialysis;Therapy in Nephrology & Hypertension;2008

4. Genetic and clinical factors influence the baseline permeability of the peritoneal membrane;Kidney International;2005-06

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