Successful Use of Combined Intraperitoneal Azlocillin and Aminogl Ycoside in the Treatment of Dialysis Associated Pseudomonas Peritonitis

Abstract

Pseudomonas peritonitis associated with peritoneal dialysis is usually severe and difficult to treat. Prolonged courses of aminoglycoside antibiotics carry the risk of ototoxicity and nephrotoxicity. Azlocillin, a new acylureidopenicillin with potent antipseudomonal activity, was used successfully in combination with an aminoglycoside in the treatment of two patients with dialysis -associated pseudomonas peritonitis. Serum and peritoneal fluid antibiotic levels were monitored and a marked synergistic effect was observed with this antimicrobial combination. Azlocillin may have a useful aminoglycosidesparing effect in the treatment of pseudomonas peritonitis.