Adsorption of Erythropoietin and Growth Hormone to Peritoneal Dialysis Bags and Tubing-Reference-Cited by-同舟云学术

Adsorption of Erythropoietin and Growth Hormone to Peritoneal Dialysis Bags and Tubing

Published:2001-01 Issue:1 Volume:21 Page:1-3
ISSN:0896-8608
Container-title:Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
language:en
Short-container-title:Perit Dial Int

Author:

Schröder Cornelis H.¹,Swinkels Leon M.J.W.²,Reddingius Roel E.³,Sweep Fred G.J.²,Willems Hans L.⁴,Monnens Leo A.H.³

Affiliation:

1. Department of Pediatrics Wilhelmina Children's University Hospital, Utrecht

2. Department of Chemical Endocrinology University Hospital, Nijmegen The Netherlands

3. Department of Pediatrics University Hospital, Nijmegen The Netherlands

4. Clinical Chemistry University Hospital, Nijmegen The Netherlands

Abstract

Objective To study the adsorption of erythropoietin and growth hormone to dialysis bags and tubing. Design In vitro study in which radiolabeled erythropoietin and recombinant human growth hormone were added to small-volume (50- and 250-mL) dialysis bags. Recovery was measured after 15-minute dwells. Experiments were performed in triplicate. Setting University hospital. Results Adsorption of erythropoietin and growth hormone was less than 7%. Conclusion Adsorption of erythropoietin and recombinant human growth hormone to dialysis bags and tubing is minimal. This finding provides another argument in favor of intraperitoneal therapy in pediatric peritoneal dialysis.

Publisher

SAGE Publications

Subject

Nephrology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/089686080102100117

Reference10 articles.

1. Absorption of Recombinant Human Growth Hormone (rhGH) following Intraperitoneal Instillation

2. Intraperitoneal administration of recombinant human erythropoietin in children on continuous ambulatory peritoneal dialysis

3. Pharmacokinetics of recombinant human erythropoietin in children treated with continuous ambulatory peritoneal dialysis

4. Increase of the Bioavailabllity of Intraperitoneal Erythropoietin in Children on Peritoneal Dialysis by Administration in Small Dialysis Bags

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