1. The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, UK
2. Northern Ireland Clinical Trials Unit, Belfast, UK
3. Critical Care Unit, King’s College Hospital NHS Foundation Trust, London, UK
4. Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK
5. Centre of Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, UK