Differential Effect of Amphetamine Optical Isomers on Bender Gestalt Performance of the Minimally Brain Dysfunctioned

Author:

Arnold L. Eugene1,Huestis Robert D.2,Wemmer Douglas,Smeltzer Donald J.

Affiliation:

1. Eugene Arnold is an attending staff physician at Ohio State University Hospitals and associate professor of psychiatry and pediatrics. He was educated at Ohio State University (MD) and Johns Hopkins (MEd).

2. Robert Huestis was trained in psychiatry at Ohio State University. Requests for reprints should be sent to Dr. Arnold, Department of Psychiatry, Ohio State University, Columbus, Ohio 43210.

Abstract

As part of a double-blind Latin-square crossover comparison of placebo, dextroamphetamine and levoamphetamine in 31 hyperkinetic minimally brain dysfunctioned children, Bender Gestalt tests were administered. On mean Koppitz error scores, dextroamphetamine showed significant benefit over predrug, placebo, and levoamphetamine. Predrug, placebo, and levoamphetamine Koppitz scores were not significantly different from one another, though all three were significantly worse than dextroamphetamine. Dosages of the two isomers were not significantly different, and behavioral effects were comparable.

Publisher

SAGE Publications

Subject

General Health Professions,Education,Health(social science)

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