Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia-Reference-Cited by-同舟云学术

Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia

Published:2023-01 Issue: Volume:32 Page:096368972311710
ISSN:0963-6897
Container-title:Cell Transplantation
language:en
Short-container-title:Cell Transplant

Author:

Var Susanna R.¹²^ORCID,Strell Phoebe²³^ORCID,Johnson Sether T.¹²,Roman Alex⁴,Vasilakos Zoey²⁴,Low Walter C.¹²³^ORCID

Affiliation:

1. Department of Neurosurgery, Medical School, University of Minnesota, Minneapolis, MN, USA

2. Stem Cell Institute, Medical School, University of Minnesota, Minneapolis, MN, USA

3. Department of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA

4. Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA

Abstract

Microglia are associated with a wide range of both neuroprotective and neuroinflammatory functions in the central nervous system (CNS) during development and throughout lifespan. Chronically activated and dysfunctional microglia are found in many diseases and disorders, such as Alzheimer’s disease, Parkinson’s disease, and CNS-related injuries, and can accelerate or worsen the condition. Transplantation studies designed to replace and supplement dysfunctional microglia with healthy microglia offer a promising strategy for addressing microglia-mediated neuroinflammation and pathologies. This review will cover microglial involvement in neurological diseases and disorders and CNS-related injuries, current microglial transplantation strategies, and different approaches and considerations for generating exogenic microglia.

Funder

Suzanne M. Schwarz Fund

NIH

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/09636897231171001

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