Challenges in stem cell-derived islet replacement therapy can be overcome

Author:

Abdulreda Midhat H.123ORCID,Berggren Per-Olof14

Affiliation:

1. Diabetes Research Institute, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA

2. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA

3. Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, USA

4. The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, Stockholm, Sweden

Abstract

In this Commentary, we echo the conclusions of a recent review titled “ The promise of stem cell-derived islet replacement therapy,” which highlighted recent advances in producing glucose responsive “islets” from stem cells and the benefits of their use in islet transplant therapy in type 1 diabetes (T1D). The review also outlined the status of clinical islet transplantation and the challenges that have prevented it from reaching its full therapeutic promise. We agree with the conclusions of the review and suggest that the identified challenges may be overcome by using the eye anterior chamber as an islet transplant site. We anticipate that the combination of stem cell-derived islets and intraocular transplant could help this promising T1D therapy reach full fruition.

Funder

Diabetes Wellness Foundation

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

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