Behavioral Effects of Neural Transplantation

Author:

Emerich Dwaine F.1,Ragozzino Michael2,Lehman Michael N.3,Sanberg Paul R.4

Affiliation:

1. CytoTherapeutics, Inc., Providence, RI, USA 02906

2. Department of Psychology, University of Virginia, Gilmer Hall, Charlottesville, VA 22903, USA

3. Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA

4. Division of Neurological Surgery, University of South Florida College of Medicine, Tampa, FL 33612, USA

Abstract

Considerable evidence suggests that transplantation of fetal neural tissue ameliorates the behavioral deficits observed in a variety of animal models of CNS disorders. However, it is also becoming increasingly clear that neural transplants do not necessarily produce behavioral recovery, and in some cases have either no beneficial effects, magnify existing behavioral abnormalities, or even produce a unique constellation of deficits. Regardless, studies demonstrating the successful use of neural transplants in reducing or eliminating behavioral deficits in these animal models has led directly to their clinical application in human neurodegenerative disorders such as Parkinson's disease. This review examines the beneficial and deleterious behavioral consequences of neural transplants in different animal models of human diseases, and discusses the possible mechanisms by which neural transplants might produce behavior recovery.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

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