Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte Transplantation-Reference-Cited by-同舟云学术

Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte Transplantation

Published:2000-09 Issue:5 Volume:9 Page:671-673
ISSN:0963-6897
Container-title:Cell Transplantation
language:en
Short-container-title:Cell Transplant

Author:

Kobayashi Naoya¹²,Ito Masahiro¹,Nakamura Junta¹,Cai Jin¹,Hammel James M.¹,Fox Ira J.¹

Affiliation:

1. Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198

2. First Department of Surgery, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan

Abstract

Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl4). Intrasplenic transplantation of 50 × 106 primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/096368970000900512

Reference8 articles.

1. Survival, organization, and function of microcarrier-attached hepatocytes transplanted in rats.

2. Hepatocyte transplantation: Back to the future

3. Hepatocyte transplantation in rats with decompensated cirrhosis

4. TREATMENT OF SURGICALLY INDUCED ACUTE LIVER FAILURE BY TRANSPLANTATION OF CONDITIONALLY IMMORTALIZED HEPATOCYTES1,2

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