Stem Cells: Recent Developments Redefining Epilepsy Therapy

Author:

Alayli Adam1ORCID,Lockard Gavin1,Gordon Jonah1ORCID,Connolly Jacob1,Monsour Molly1,Schimmel Samantha1,Dela Peña Ike2ORCID,Borlongan Cesar V.3ORCID

Affiliation:

1. University of South Florida Morsani College of Medicine, Tampa, FL, USA

2. Department of Pharmaceutical and Administrative Sciences, Loma Linda University, Loma Linda, CA, USA

3. Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, USA

Abstract

The field of stem cell therapy is growing rapidly and hopes to offer an alternative solution to diseases that are historically treated medically or surgically. One such focus of research is the treatment of medically refractory epilepsy, which is traditionally approached from a surgical or interventional standpoint. Research shows that stem cell transplantation has potential to offer significant benefits to the epilepsy patient by reducing seizure frequency, intensity, and neurological deficits that often result from the condition. This review explores the basic science progress made on the topic of stem cells and epilepsy by focusing on experiments using animal models and highlighting the most recent developments from the last 4 years.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

Reference64 articles.

1. WHO. Epilepsy In WHO Fact Sheets; 2022. https://www.who.int/en/news-room/fact-sheets/detail/epilepsy [accessed 2022 Nov 15].

2. Seizures and Epilepsy: An Overview for Neuroscientists

3. Stem Cell Therapy in Treating Epilepsy

4. A Randomized, Controlled Trial of Surgery for Temporal-Lobe Epilepsy

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