Transendocardial CD34+ Cell Transplantation in Noncompaction Cardiomyopathy

Author:

Cerar Andraz1,Zemljic Gregor1,Frljak Sabina1,Jaklic Martina1,Poglajen Gregor1,Sever Matjaz2,Cukjati Marko3,Vrtovec Bojan1

Affiliation:

1. Advanced Heart Failure and Transplantation Center, Department of Cardiology, UMC Ljubljana, Ljubljana, Slovenia

2. Department of Hematology, UMC Ljubljana, Ljubljana, Slovenia

3. National Blood Transfusion Institute, Ljubljana, Slovenia

Abstract

Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in the altered formation of coronary microvessels with a resulting decrease in myocardial perfusion. Transendocardial CD34+ cell transplantation has been shown to increase myocardial perfusion and function in patients with non-ischemic heart failure. In our first-in-man case study, we investigated the feasibility, safety and clinical effect of transendocardial CD34+ cell therapy in a patient with noncompaction cardiomyopathy.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

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