The Roles of γδ T Cells in Hematopoietic Stem Cell Transplantation-Reference-Cited by-同舟云学术

The Roles of γδ T Cells in Hematopoietic Stem Cell Transplantation

Published:2020-01-01 Issue: Volume:29 Page:096368972096698
ISSN:0963-6897
Container-title:Cell Transplantation
language:en
Short-container-title:Cell Transplant

Author:

Ye Wanyi¹^ORCID,Kong Xueting¹,Zhang Wenbin¹,Weng Zheng¹,Wu Xiuli¹²^ORCID

Affiliation:

1. Institute of Hematology, School of Medicine, Jinan University, Guangzhou, China

2. Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China

Abstract

The αβ T-cell-depleted hematopoietic stem cell transplantation (HSCT) leads to lower relapse and better outcome, and may correlate strongly with expansion of donor-derived γδ T cells. γδ T cells play an important role in immune reconstitution and can exert a graft-versus-leukemia effect after HSCT. This review showed the recent literature on immune functions of γδ T cells after HSCT. The discrepancies between studies of γδ T cells in graft-versus-host disease may cause by its heterogeneous and various distinct subsets. And reconstitution of γδ T cells may play a potential immunoregulatory role in the infections after HSCT.

Funder

the National Natural Science Foundation of China

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/0963689720966980

Reference100 articles.

1. Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic γδ T Lymphocytes to Tumor Beds

2. Comparative Efficacy and Clinical Outcomes of Haploidentical Stem Cell Transplantation to Other Stem Sources for Treatment in Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients: A Systematic Review and Meta-Analysis

3. Ex Vivo T Cell-Depleted Hematopoietic Stem Cell Transplantation for Adult Patients with Acute Myelogenous Leukemia in First and Second Remission: Long-Term Disease-Free Survival with a Significantly Reduced Risk of Graft-versus-Host Disease