Effect of Subacute Toluene Administration on the Enkephalinergic Neuromodulatory System in Rats and Protective Action of Ganglioside Treatments-Reference-Cited by-同舟云学术

Effect of Subacute Toluene Administration on the Enkephalinergic Neuromodulatory System in Rats and Protective Action of Ganglioside Treatments

Published:1994-05 Issue:3 Volume:10 Page:155-161
ISSN:0748-2337
Container-title:Toxicology and Industrial Health
language:en
Short-container-title:Toxicol Ind Health

Author:

De Gandarias Juan M.¹,Echevarria Enrique¹,Serrano Roberto¹,Irazusta Jon¹,Casis Luis¹

Affiliation:

1. Department of Physiology Medical School University of the Basque Country Bilbao, Spain

Abstract

Gangliosides perform protective functions in the central nervous system. This paper describes a study of the effect of ganglioside administration on toluene neurotoxicity. Rat brain met-enkephalin immunostaining in the central amygdaloid nuclei showed changes in rats treated simultaneously with gangliosides and toluene with respect to rats treated with toluene alone. It is suggested that gangliosides prevent toluene neurotoxicity at this level, leading to hypothetical neurobehavioral changes.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/074823379401000305

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2. Toluene-induced activation of certain hypothalamic and median eminence catecholamine nerve terminal systems of the male rat and its effects on anterior pituitary hormone secretion

3. Acute effects of toluene on circadian rhythms of sleep-wakefulness and brain monoamine metabolism in rats

4. Effects of subacute treatment with toluene on central monoamine receptors in the rat. Reduced affinity in [3H]5-hydroxytryptamine binding sites and in [3H]spiperone binding sites linked to dopamine receptors

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3. Effects of Acute Benzene Exposure on Brain Enkephalin Immunostaining and Degradation;Neurotoxicology and Teratology;1998-11

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