The relationship of PON1 QR 192 and LM 55 polymorphisms with serum paraoxonase activities of Turkish diabetic patients-Reference-Cited by-同舟云学术

The relationship of PON1 QR 192 and LM 55 polymorphisms with serum paraoxonase activities of Turkish diabetic patients

Published:2011-04-19 Issue:10 Volume:27 Page:873-878
ISSN:0748-2337
Container-title:Toxicology and Industrial Health
language:en
Short-container-title:Toxicol Ind Health

Author:

Altuner Durdu¹,Ates Ilker¹,Suzen Sinan H¹,Koc Gonul Varan²,Aral Yalcin²,Karakaya Asuman¹

Affiliation:

1. Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan, Ankara, Turkey

2. Endocrinology Clinic, Ankara Training and Research Hospital, Ankara, Turkey

Abstract

Paraoxonase (PON1) is a serum esterase responsible for the protection against xenobiotics toxicity such as paraoxon. Alterations in PON1 concentrations have been reported in a variety of diseases including diabetes mellitus (DM). It has been shown that the serum PON1 concentration and activity are decreased in patients with both type 1 and type 2 DM. This study aimed to investigate the lipid profiles and the relationship between PON1 activity and PON1, QR192 and LM55 polymorphisms in Turkish type 2 diabetic patients and non-diabetic control subjects. According to our results, RR variant had significantly higher PON activity than QQ and QR variants ( p < 0.01) and LL variant had significantly higher PON activity than MM variant in both control and patient groups ( p < 0.05). In conclusion, we found that PON1 192RR and 55LL genotypes are associated with higher PON activity than QQ and MM genotypes. This may be more protective to lipid peroxidation.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0748233711399317

Reference28 articles.

1. Serum Paraoxonase Activity, Concentration, and Phenotype Distribution in Diabetes Mellitus and Its Relationship to Serum Lipids and Lipoproteins

2. Paraoxonase 55 and 192 polymorphism and its relationship to serum paraoxonase activity and serum lipids in Turkish patients with non-insulin dependent diabetes mellitus

3. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.

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