Effect of Pleurotus florida lectin (PFL) on arsenic-induced activities of splenoctyes in rat-Reference-Cited by-同舟云学术

Effect of Pleurotus florida lectin (PFL) on arsenic-induced activities of splenoctyes in rat

Published:2012-08-22 Issue:4 Volume:30 Page:336-346
ISSN:0748-2337
Container-title:Toxicology and Industrial Health
language:en
Short-container-title:Toxicol Ind Health

Author:

Rana Tanmoy¹,Bera Asit Kumar¹²,Bhattacharya Debasis¹²,Das Subhashree¹,Pan Diganta¹,Das Subrata Kumar¹

Affiliation:

1. Indian Veterinary Research Institute, Eastern Regional Station, Kolkata, India

2. National Research Centre on Yak, Dirang, West Kameng Distrct, Arunachal Pradesh, India

Abstract

The present study was undertaken to investigate the protective effect of Pleurotus florida lectin (PFL) against arsenic-induced cytotoxicity and oxidative damages in freshly isolated splenocytes of rodents. Our finding indicated that arsenic caused reduction in cell adhesion, morphological alterations, cell proliferation, nitro blue tetrazolium (NBT) index, superoxide dismutase (SOD) activity, catalase (CAT) activity and relative mRNA expression of SOD2 in relation to housekeeping gene glyceraldehyde 3-phosphate dehydrogenase ( GAPDH) and increased production of nitric oxide (NO), protein carbonyl (PC) and lipid peroxidation levels (LPO) assembled to play key factors for cytotoxicity and oxidative stress. PFL normalized cellular damages and enhanced SOD production pathway relating to gene expression. Further studies are needed to address effective phytochemicals of the edible mushroom and their mechanism.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0748233712456064

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