Association of Circulating Endothelial Progenitor Cells (CD14+-EPC) With Renal Function in Patients With Coronary Artery Disease

Abstract

Background: The relationships between the endothelial progenitor cells (EPCs)-CD34+ and CD14+ and coronary artery disease (CAD) were reported and the association of CD34+ cells with renal function was studied previously. Another kind EPC-CD14+ cell and its association with renal function in patients with CAD have not been reported yet. Our aim was to assess CD14+ cell counts versus renal function in CAD. Methods and Results: We studied 242 patients with severe angiographic CAD and 30 healthy control participants. The CD14+ cells were enumerated by flow cytometry. With lowering glomerular filtration rate (GFR), CD14+ cell numbers (percentage of lymphocytes, median and interquartile range) decreased: 0.04 (0.03-0.06), 0.03 (0.02-0.05), 0.02 (0.01-0.03) for estimated glomerular filtration rate (eGFR) ≥90, 60 to 89, and 30 to 89 mL/min per 1.73 m2, respectively ( P < .001 for trend). The CD14+ cell counts correlated with eGFR ( r = .27, P = .03). By multivariate liner regression analysis, the difference remains significant ( P = .02). Conclusions: The CD14+ cell depletion is associated with renal dysfunction in CAD.