Evaluation of the Coagulation Profile Among Oral and Vaginal Combined Hormonal Contraceptive Users Using Sonoclot Coagulation Analyzer-Reference-Cited by-同舟云学术

Evaluation of the Coagulation Profile Among Oral and Vaginal Combined Hormonal Contraceptive Users Using Sonoclot Coagulation Analyzer

Published:2012-01-23 Issue:6 Volume:18 Page:576-581
ISSN:1076-0296
Container-title:Clinical and Applied Thrombosis/Hemostasis
language:en
Short-container-title:Clin Appl Thromb Hemost

Author:

Brandy Kyle R.¹,Meyer Rachel M.¹,Luo Xianghua²,Rao Gundu H.³,Datta Yvonne H.⁴,Divani Afshin A.¹⁵⁶

Affiliation:

1. Department of Neurology, University of Minnesota, Minneapolis, MN, USA

2. Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA

3. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA

4. Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, USA

5. Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA

6. Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA

Abstract

Combined hormonal contraceptives possess an inherent risk of thrombus-related events. The purpose of this study is to elucidate alterations in the coagulation profile among young women using combined oral contraceptive (COC) or combined vaginal contraceptive (CVC) compared to a normal, healthy, female control group using the Sonoclot coagulation analyzer. We enrolled 159 participants (64 control individuals, 51 COC users, and 44 CVC users). Each participant completed a survey of medical history, family medical history, and lifestyle choices. Citrated venous whole blood was collected and analyzed using the Sonoclot coagulation analyzer. After adjusting for age, race, alcohol consumption, sleeping habits, and family history of cardiovascular disease, and stroke, we observed COC and CVC users had mostly similar coagulation profiles except when compared to the control, and COC and CVC users had an elevated glass bead peak signal while COC users had a shorter peak time.

Publisher

SAGE Publications

Subject

Hematology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1076029611434526

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