Hemostatic Abnormalities in Patients With Thrombotic Complications on Maintenance Hemodialysis

Author:

Inoue Akiko1,Wada Hideo1,Takagi Mikio2,Yamamuro Miho1,Mukai Kenji2,Nakasaki Takahiro1,Shimura Minori1,Hiyoyama Kazuyo1,Deguchi Hiroshi1,Gabazza Esteban C.3,Mori Yoshitaka1,Nishikawa Masakatsu1,Deguchi Katsumi2,Shiku Hiroshi1

Affiliation:

1. Second Department of Internal Medicine, Mie University School of Medicine, Tsu-city, Mie-ken, Japan

2. Department of Internal Medicine, Ise General Hospital, Ise city, Mie-ken, Japan

3. Third Department of Internal Medicine, Mie University School of Medicine, Tsu-city, Mie-ken, Japan

Abstract

Before hemodialysis (HD), plasma levels of tissue factor (TF), free-TF pathway inhibitor (TFPI) and thrombo modulin (TM) were significantly higher in patients with HD than in healthy volunteers. Plasma levels of (T-F) TFPI and plasmin plasmin inhibitor complex (PPIC) were significantly higher in patients with HD than in healthy volunteers. During HD, plasma levels of TF and (T-F) TFPI were not significantly increased, but plasma levels of total TFPI and free TFPI at 1 hour after and at the end of HD were significantly increased, compared with levels before start of HD. Plasma level of PPIC 1 hour after start of HD was significantly higher than before start of HD, and plasma levels of thrombin antithrombin com plex (TAT). PPIC. D-dimer. TM, and protein C (PC) at the end of HD were significantly higher than before start of HD. In patients with thrombosis complications, plasma TF levels were significantly higher than in patients without thrombotic com plications during HD. Plasma levels of PC were significantly lower in patients with thrombotic complications than in patients without thrombotic complications. There was no significant difference between both groups during HD in hemostatic pa rameters, with the exception of TF and PC. Hemostatic abnormalities existed in patients with HD; espe cially, increased TF and decreased PC might cause thrombotic complications.

Publisher

SAGE Publications

Subject

Hematology,General Medicine

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