Apixaban Versus Enoxaparin in Elective Major Orthopedic Surgery

Author:

Maniscalco Pietro1,Caforio Marco1,Imberti Davide2,Porcellini Giuseppe3,Benedetti Raffaella2

Affiliation:

1. Department of Orthopaedics and Traumatology, Piacenza Hospital, Piacenza, Italy

2. Department of Internal Medicine, Piacenza Hospital, Piacenza, Italy

3. Department of Orthopaedic Shoulder Surgery, Cattolica, Rimini, Italy

Abstract

Despite current guidelines recommendations about anticoagulant prophylaxis, many studies have shown an high venous thromboembolism (VTE) incidence in patients undergoing total hip and knee arthroplasty. A number of anticoagulants are currently available, but they have some limitations that affect their applicability and consequently their effectiveness. Several new oral anticoagulants (NOACs) have been developed in an attempt to overcome these limitations. Apixaban is a NOAC that selectively inhibits the coagulation factor Xa; it is approved for the prevention of VTE after total hip replacement and total knee replacement surgery. This review examines the results of main trials designed to test efficacy and safety of apixaban in major elective orthopedic surgery.

Publisher

SAGE Publications

Subject

Hematology,General Medicine

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