Mean Platelet Volume and Related Factors in Patients at Different Stages of Diabetic Nephropathy-Reference-Cited by-同舟云学术

Mean Platelet Volume and Related Factors in Patients at Different Stages of Diabetic Nephropathy

Published:2012-08-21 Issue:2 Volume:20 Page:190-195
ISSN:1076-0296
Container-title:Clinical and Applied Thrombosis/Hemostasis
language:en
Short-container-title:Clin Appl Thromb Hemost

Author:

Turgutalp Kenan¹,Özhan Onur²,Akbay Esen²,Tombak Anıl³,Tiftik Naci³,Ozcan Turkay⁴,Yılmaz Sercan¹,Helvacı İlter⁵,Kiykim Ahmet¹

Affiliation:

1. Division of Nephrology, Department of Internal Medicine, School of Medicine, Mersin University, Mersin, Turkey

2. Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Mersin University, Mersin, Turkey

3. Division of Hematology, Department of Internal Medicine, School of Medicine, Mersin University, Mersin, Turkey

4. Department of Cardiology, School of Medicine, Mersin University, Mersin, Turkey

5. Silifke School of Applied Technology and Management, Department of Business Information Management, Mersin University, Mersin, Turkey

Abstract

Introduction: Mean platelet volume (MPV) is an independent cardiovascular disease predictor, and characteristics of MPV in patients with diabetic nephropathy (DN) are not well known. Aim: To determine the MPV levels in patients at different stages of DN. Patients and Methods: The MPV levels were investigated in healthy participants (group 1, n = 157), patients with type 2 diabetes mellitus without complication (group 2, n = 160), diabetic patients with clinical proteinuria (group 3, n = 144), and in patients with chronic kidney disease due to DN (group 4, n = 160). Findings: The MPV level was higher in all diabetic patients than that in normal participants ( P < .05). The MPV values had a positive correlation with the serum creatinine and proteinuria, and a negative correlation with the glomerular filtration rate ([GFR] P < .001 for all, r values; .72, and .82, and −.92, respectively). Conclusion: The MPV values were higher in diabetic groups than that in normal participants. Both GFR and proteinuria were the most powerful determinants of MPV.

Publisher

SAGE Publications

Subject

Hematology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1076029612456734

Reference33 articles.

1. Heterogeneity of human platelets

2. Platelet activation: assessment and quantification

3. A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function

4. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis

5. Mean platelet volume and the extent of coronary artery disease: Results from a large prospective study

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