Novel Biomarkers for Coronary Restenosis Occurrence After Drug-Eluting Stent Implantation in Patients With Diabetes Having Stable Coronary Artery Disease

Author:

Gabbasov Zufar1,Kozlov Sergey1,Melnikov Ivan12,Byazrova Svetlana1,Saburova Olga1,Prokofieva Lyudmila1,Caprnda Martin3,Curilla Eduard4,Gaspar Ludovit3,Rodrigo Luis5,Kruzliak Peter67,Smirnov Vladimir1

Affiliation:

1. Russian Cardiology Research and Production Complex, Moscow, Russian Federation

2. Institute of Biomedical Problems of Russian Academy of Sciences, Moscow, Russian Federation

3. 1st Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia

4. Department of Cardiology, East Slovak Institute of Cardiovascular Diseases, Kosice, Slovakia

5. Faculty of Medicne, University of Oviedo, Central University Hospital of Asturias (HUCA), Oviedo, Spain

6. Department of Internal Medicine, Brothers of Mercy Hospital, Brno, Czech Republic

7. 2nd Department of Surgery, Faculty of Medicine, Masaryk University and St. Anne’s University Hospital, Brno, Czech Republic

Abstract

The purpose of the study was to assess whether the occurrence of restenosis is associated with CD45+ platelet count and neutrophil to lymphocyte ratio in patients with type 2 diabetes mellitus (DM) after drug-eluting stent (DES) implantation for stable coronary artery disease (CAD). The study comprised 126 patients, including 55 patients with type 2 DM and stable CAD who underwent elective coronary artery stenting with DES and follow-up angiography within 6 to 12 months. Blood samples were collected from each patient on the morning of the coronary angiography procedure. The variables related to in-stent restenosis were selected by logistic regression analysis. The logistic regression analysis showed that 2 inflammatory factors, CD45+ platelet count (odds ratio [OR] = 4.51, 95% confidence interval [CI]: 1.50-13.50, P = .007) and neutrophil to lymphocyte ratio (OR = 3.09, 95% CI: 1.05-9.10, P = .04), were significantly associated with the risk of in-stent restenosis after stenting with DES in patients with stable CAD and type 2 DM. A receiver operator characteristic curve analysis indicated that the area under the curve was 0.83% (0.05%; P < .001), which showed that the logistic model had good predictive accuracy (based on CD45+ platelet count and neutrophil to lymphocyte ratio) for the risk of in-stent restenosis development in DES in patients with CAD and type 2 DM. Two novel biomarkers of restenosis, CD45+ platelet count and neutrophil to lymphocyte ratio, may be effectively used to predict in-stent restenosis after DES implantation in patients with CAD and type 2 DM.

Funder

Russian Science Foundation

Publisher

SAGE Publications

Subject

Hematology,General Medicine

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