Significance of αIIbβ3 in Subacute Stent ThrombosisAfter Percutaneous Coronary Intervention

Author:

Inami Norihito1,Nomura Shosaku2,Kajiura Takayuki1,Yamada Kohichi1,Nakamori Hisato1,Takahashi Nobuyuki1,Tsuda Nobuyuki1,Fukuhara Shirou2,Iwasaka Toshiji1

Affiliation:

1. Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan

2. First Department of Internal Medicine, Kansai Medical University, Osaka, Japan

Abstract

Soluble P-selectin and whole blood aggregation (WBA) were measured after percutaneous coronary intervention in patients who then received antiplatelet therapy. One had subacute thrombosis on day 7. This patient’s WBA exhibited time-dependent enhancement. In addition, the accentuation of WBA on day 3 was observed when anti-αIIbβ3 antibody was added. The remaining 22 patients were divided according to WBA results on day 3 with anti-αIIbβ3 antibody added (A group, WBA enhanced; B group, WBA did not enhance). WBA on day 3 was similar in the two groups. The ratio of WBA with and without anti-αIIbβ3 antibody was higher in group A than in group B. A significant time-dependent increase of soluble P-selectin was observed in the A group. These results suggest that enhancement of WBA with anti-αIIbβ3 antibody after percutaneous coronary intervention predicts subacute thrombosis.

Publisher

SAGE Publications

Subject

Hematology,General Medicine

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