Atypical Hepatic Mesenchymal Hamartoma: Histologic Appearance, Immunophenotype, and Molecular Findings-Reference-Cited by-同舟云学术

Atypical Hepatic Mesenchymal Hamartoma: Histologic Appearance, Immunophenotype, and Molecular Findings

Published:2018-11-29 Issue:4 Volume:22 Page:365-369
ISSN:1093-5266
Container-title:Pediatric and Developmental Pathology
language:en
Short-container-title:Pediatr Dev Pathol

Author:

El Demellawy Dina¹,Lee James YJ²,McDonell Laura³,Dyment David A³,Knisely AS⁴,McGowan-Jordan Jean⁵,Ngan Bo⁶,Finegold Milton⁷,Kapur Raj P⁸,Nasr Ahmed⁹

Affiliation:

1. Department of Pathology, Children’s Hospital of Eastern Ontario and University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada

2. University of Ottawa, Ottawa, Ontario, Canada

3. Department of Clinical Genetics, Children’s Hospital of Eastern Ontario, Ottawa, Ontario, Canada

4. Institut für Pathologie, Medizinische Universität Graz, Graz, Austria

5. Department of Genetics, Children’s Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario, Canada

6. Department of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada

7. Department of Pathology, Baylor College of Medicine, Houston, Texas

8. Department of Pathology, Seattle Children’s Hospital, Seattle, Washington

9. Department of Pediatric Surgery, Children’s Hospital of Eastern Ontario and University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada

Abstract

Hepatic mesenchymal hamartoma is a rare benign neoplasm principally encountered in young children. Its origin is unknown. We report an unusual hepatic mesenchymal hamartoma in a 7-month-old girl, including histopathologic findings, immunophenotype, and karyotype. Chromosomal microarray analysis of tumoral tissue and circulating lymphocytes found 4 copies of a segment at 1q44 and fluorescence in situ hybridization indicated tandem triplication, ascribed to expansion of a paternal tandem duplication. This genetic abnormality may have played a role in pathogenesis.

Publisher

SAGE Publications

Subject

General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology, and Child Health

Link

http://journals.sagepub.com/doi/pdf/10.1177/1093526618806750

Reference18 articles.

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2. Hepatic Mesenchymal Hamartoma Associated with Mesenchymal Stem Villous Hyperplasia of the Placenta

3. Mesenchymal Hamartoma of Liver

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