A Pediatric Case of High-Grade Secretory Carcinoma of the Maxillary Sinus With <i>ETV6::NTRK3</i> Gene Fusion, Therapeutic Implications, and Review of the Literature-Reference-Cited by-同舟云学术

A Pediatric Case of High-Grade Secretory Carcinoma of the Maxillary Sinus With ETV6::NTRK3 Gene Fusion, Therapeutic Implications, and Review of the Literature

Published:2022-11-30 Issue:1 Volume:26 Page:59-64
ISSN:1093-5266
Container-title:Pediatric and Developmental Pathology
language:en
Short-container-title:Pediatr Dev Pathol

Author:

Cardoni Antonello¹^ORCID,De Vito Rita¹,Milano Giuseppe Maria²,De Pasquale Maria Debora²,Alaggio Rita¹

Affiliation:

1. Pathology Unit, Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

2. Pediatric Haematology/Oncology Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

Abstract

Secretory carcinoma (SC) is a salivary gland tumor with a generally low grade microscopic appearance, a characteristic immunophenotype, and a recurrent translocation leading to ETV6::NTRK3 fusion gene. Rare cases are reported in children. The maxillary sinus is an unusual localization. SC have an overall favorable prognosis, but cases with high grade morphology have been described in adult population and are related to a more aggressive clinical course. We present a pediatric case of secretory carcinoma involving the maxillary sinus with high grade morphology, with a review of the literature of secretory carcinomas with high grade component.

Publisher

SAGE Publications

Subject

General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology and Child Health

Link

http://journals.sagepub.com/doi/pdf/10.1177/10935266221138706

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