The role of ultrasound in systemic sclerosis: On the cutting edge to foster clinical and research advancement

Author:

Hughes Michael1ORCID,Bruni Cosimo2,Cuomo Giovanna3,Delle Sedie Andrea4ORCID,Gargani Luna5,Gutierrez Marwin67,Lepri Gemma2,Ruaro Barbara8,Santiago Tania910ORCID,Suliman Yossra11ORCID,Watanabe Shinji12,Iagnocco Annamaria13,Furst Daniel21415,Bellando-Randone Silvia216

Affiliation:

1. Department of Rheumatology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

2. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

3. Department of Medicine of Precision, University of Naples L. Vanvitelli, Naples, Italy

4. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

5. Institute of Clinical Physiology, National Research Council, Pisa, Italy

6. Division of Musculoskeletal and Rheumatic Diseases, National Institute of Rehabilitation, Mexico City, Mexico

7. Rheumatology Center of Excellence, Mexico City, Mexico

8. Pulmonology Department, University Hospital of Cattinara, Trieste, Italy

9. Rheumatology Department, Centro Hospitalar e Universitáro de Coimbra, Coimbra, Portugal

10. Faculty of Medicine, University of Coimbra, Portugal

11. Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt

12. Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan

13. Academic Rheumatology Centre, Università degli Studi di Torino, Turin, Italy

14. Department of Medicine, Division of Rheumatology, University of California Los Angeles, Los Angeles, CA, USA

15. University of Washington, Seattle, WA, USA

16. Department of Geriatric Medicine, Division of Rheumatology, Careggi University Hospital, Florence, Italy

Abstract

Ultrasound has been widely explored in systemic sclerosis in the clinical and research settings. Ultrasound allows a non-invasive and ionising radiation-free ‘window’ into this complex disease and is well-suited to repeated examinations. Ultrasound provides novel insights into the pathogenesis and measurement of disease in systemic sclerosis, including early (preclinical) internal organ involvement. The purpose of this review is to describe the role of ultrasound to foster clinical and research advancements in systemic sclerosis relating to (1) musculoskeletal, (2) digital ulcer, (3) lung disease and (4) skin disease. We also highlight unmet needs which much be addressed for ultrasound to assume a central role in systemic sclerosis clinical care and research.

Publisher

SAGE Publications

Subject

Immunology,Rheumatology,Immunology and Allergy

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