Review Article: Genetics of Alzheimer Disease-Reference-Cited by-同舟云学术

Review Article: Genetics of Alzheimer Disease

Published:2010-11-02 Issue:4 Volume:23 Page:213-227
ISSN:0891-9887
Container-title:Journal of Geriatric Psychiatry and Neurology
language:en
Short-container-title:J Geriatr Psychiatry Neurol

Author:

Bekris Lynn M.¹,Yu Chang-En¹,Bird Thomas D.²,Tsuang Debby W.³

Affiliation:

1. Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA

2. Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA

3. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA,

Abstract

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOEε4 allele). Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD. In this article, we provide an overview of the clinical and genetic features of AD.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0891988710383571

Reference176 articles.

1. EPIDEMIOLOGY OF NEURODEGENERATION

2. Global prevalence of dementia: a Delphi consensus study

3. Dementia and Alzheimer Disease Incidence

4. Genetic aspects of Alzheimer disease

5. Early-Onset Autosomal Dominant Alzheimer Disease: Prevalence, Genetic Heterogeneity, and Mutation Spectrum

Cited by 757 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Modifying Alzheimer’s disease pathophysiology with photobiomodulation: model, evidence, and future with EEG-guided intervention;Frontiers in Neurology;2024-08-23

2. Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis);Ageing Research Reviews;2024-08

3. Alzheimer's Disease and Vascular Dementia, Connecting and Differentiating Features;Current Alzheimer Research;2024-07-29

4. Alzheimer’s disease: risk factors, cellular and molecular basis of pathogenesis, analysis of pathogenetic mechanisms in comparison with amyotrophic lateral sclerosis;Kazan medical journal;2024-07-25

5. Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease;Annual Review of Biophysics;2024-07-16