Familial Dementia with Lewy Bodies with an Atypical Clinical Presentation-Reference-Cited by-同舟云学术

Familial Dementia with Lewy Bodies with an Atypical Clinical Presentation

Published:2003-03 Issue:1 Volume:16 Page:59-64
ISSN:0891-9887
Container-title:Journal of Geriatric Psychiatry and Neurology
language:en
Short-container-title:J Geriatr Psychiatry Neurol

Author:

Bonner Lauren T.¹,Tsuang Debby W.¹,Cherrier Monique M.²,Eugenio Charisma J.³,Du Jennifer Q.³,Steinbart Ellen J.⁴,Limprasert Pornprot⁵,La Spada Albert R.⁶,Seltzer Benjamin⁷,Bird Thomas D.⁸,Leverenz James B.⁹

Affiliation:

1. Department of Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center (MIRECC), Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle

2. Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle

3. Department of Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center (MIRECC), University of Washington, Seattle

4. Department of Geriatric Research, Education and Clinical Centers, University of Washington, Seattle

5. Department of Laboratory Medicine, University of Washington, Seattle

6. Department of Laboratory Medicine, Department of Neurology, Department of Medicine (Medical Genetics), University of Washington, Seattle

7. Tulane University School of Medicine, Department of Psychiatry and Neurology and the Department of Veterans Affairs South Central MIRECC, New Orleans, Louisiana

8. Department of Geriatric Research, Education and Clinical Centers, Department of Neurology, Department of Medicine (Medical Genetics), University of Washington, Seattle

9. Department of Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center (MIRECC), Department of Parkinson’s Disease Research, Education, and Clinical Center, Department of Neurology, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle

Abstract

The authors report a case of a 64-year-old male with Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) pathology at autopsy who did not manifest the core symptoms of DLB until very late in his clinical course. His initial presentation of early executive and language dysfunction suggested a cortical dementia similar to frontotemporal lobar degeneration (FTLD). Core symptoms of DLB including dementia, hallucination, and parkinsonian symptoms were not apparent until late in the course of his illness. Autopsy revealed both brainstem and cortical Lewy bodies and AD pathology. Family history revealed 7 relatives with a history of dementia including 4 with possible or probable DLB. This case is unique because of the FTLD-like presentation, positive family history of dementia, and autopsy confirmation of DLB. ( J Geriatr Psychiatry Neurol 2003; 16:59-64)

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0891988702250585

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