Impaired Insight in Alzheimer's Disease-Reference-Cited by-同舟云学术

Impaired Insight in Alzheimer's Disease

Published:1991-10 Issue:4 Volume:4 Page:189-193
ISSN:0732-1139
Container-title:Topics in geriatrics
language:en
Short-container-title:Topics in geriatrics

Author:

Mangone Carlos A.¹,Hier Daniel B.²,Gorelick Philip B.³,Ganellen Ronald J.⁴,Langenberg Patricia⁵,Boarman Regina¹,Dollear Winifred C.¹

Affiliation:

1. Center for Alzheimer Disease at Humana Hospital-Michael Reese, University of Illinois, Chicago, IL

2. Department of Neurology, University of Illinois, Chicago, IL

3. Center for Alzheimer Disease at Humana Hospital-Michael Reese, University of Illinois, Chicago, IL, Department of Neurology, University of Illinois, Chicago, IL

4. Center for Alzheimer Disease at Humana Hospital-Michael Reese, University of Illinois, Chicago, IL, School of Public Health University of Illinois, Chicago, IL

5. School of Public Health University of Illinois, Chicago, IL

Abstract

We studied insight into illness in 41 patients with probable Alzheimer's disease. An impaired insight score was developed by measuring discrepancies between patient report and caregiver report on standard instruments of activities of daily living. Insight was more impaired in subjects with greater dementia severity and subjects with paranoid delusions. In a multivariate analysis, the best neuropsychological predictors of impaired insight were the Continuous Performance Test and the Visual Reproduction Test. We speculate that the impaired insight of Alzheimer's disease has two components: confabulation reflecting prefrontal dysfunction and anosognosia reflecting right-hemisphere dysfunction. ( J Geriatr Psychiatry Neurol 1991;4:189-193).

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/089198879100400402

Reference23 articles.

1. Critchley M. : The Parietal Lobes. London , Edward Arnold, 1953, p 250.

2. Hier DB, Gorelick PB, Shindler AG: Topics in Behavioral Neurology and Neuropsychology. Boston , Butterworths, 1987, p 165.

3. Emotional Behavior and Hemispheric Side of the Lesion

4. Neurologic fragments. II. Remarks on anosognosia, confabulation, memory, and other topics; and an appendix on self-observation*

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