Pittsburgh Compound B (11C-PIB) and Fluorodeoxyglucose (18 F-FDG) PET in Patients With Alzheimer Disease, Mild Cognitive Impairment, and Healthy Controls-Reference-Cited by-同舟云学术

Pittsburgh Compound B (11C-PIB) and Fluorodeoxyglucose (18 F-FDG) PET in Patients With Alzheimer Disease, Mild Cognitive Impairment, and Healthy Controls

Published:2010-04-29 Issue:3 Volume:23 Page:185-198
ISSN:0891-9887
Container-title:Journal of Geriatric Psychiatry and Neurology
language:en
Short-container-title:J Geriatr Psychiatry Neurol

Author:

Devanand D.P.¹,Mikhno Arthur²,Pelton Gregory H.³,Cuasay Katrina³,Pradhaban Gnanavalli³,Dileep Kumar J.S.⁴,Upton Neil⁵,Lai Robert⁵,Gunn Roger N.⁶,Libri V.⁵,Xinhua Liu ⁷,van Heertum Ronald⁸,Mann J. John⁴,Parsey Ramin V.⁴

Affiliation:

1. Division of Geriatric Psychiatry, Columbia University, New York, USA, , New York State Psychiatric Institute, Columbia University, New York, USA, College of Physicians and Surgeons, Columbia University, New York, USA

2. Division of Molecular Imaging and Neuropathology, Columbia University, New York, USA, College of Physicians and Surgeons, Columbia University, New York, USA

3. Division of Geriatric Psychiatry, Columbia University, New York, USA, New York State Psychiatric Institute, Columbia University, New York, USA, College of Physicians and Surgeons, Columbia University, New York, USA

4. Division of Molecular Imaging and Neuropathology, Columbia University, New York, USA, New York State Psychiatric Institute, Columbia University, New York, USA, College of Physicians and Surgeons, Columbia University, New York, USA

5. Neurosciences-CEDD, Essex, United Kingdom

6. GlaxoSmithKline CIC, Essex, United Kingdom

7. Department of Biostatistics, School of Public Health, Columbia University, New York, USA

8. College of Physicians and Surgeons, Columbia University, New York, USA, Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, USA

Abstract

Amyloid load in the brain using Pittsburgh compound B (11C-PIB) positron emission tomography (PET) and cerebral glucose metabolism using fluorodeoxyglucose (18F-FDG) PET were evaluated in patients with mild Alzheimer disease (AD, n = 18), mild cognitive impairment (MCI, n = 24), and controls (CTR, n = 18). 11C-PIB binding potential (BPND) was higher in prefrontal cortex, cingulate, parietal cortex, and precuneus in AD compared to CTR or MCI and in prefrontal cortex for MCI compared to CTR. For 18F-FDG, regional cerebral metabolic rate for glucose (rCMRGlu) was decreased in precuneus and parietal cortex in AD compared to CTR and MCI, with no MCI—CTR differences. For the AD—CTR comparison, precuneus BPND area under the receiver operating characteristic (ROC) curve (AUC) was 0.938 and parietal cortex rCMRGlu AUC was 0.915; for the combination, AUC was 0.989. 11C-PIB PET BPND clearly distinguished diagnostic groups and combined with 18F-FDG PET rCMRGlu, this effect was stronger. These PET techniques provide complementary information in strongly distinguishing diagnostic groups in cross-sectional comparisons that need testing in longitudinal studies.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Neurology (clinical)

Link

http://journals.sagepub.com/doi/pdf/10.1177/0891988710363715

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