Depressive Symptoms in Parkinson's Disease: A Comparison With Disabled Control Subjects

Author:

Ehmann Thomas S.1,Beninger Richard J.2,Gawel Merek J.3,Riopelle Richard J.4

Affiliation:

1. Department of Psychology, Queen's University

2. Department of Psychology, Queen's University, Department of Psychiatry, Queen's University

3. Department of Neurology, Sunnybrook Medical Centre, Toronto, Canada

4. Department of Medicine, Queen's University, Kingston

Abstract

A high incidence of depressive symptoms has been observed in patients with Parkinson's disease (PD). PD involves a loss of central monoamines, and a decrease of monoamines has been implicated in depression; therefore, it is possible that depressive symptoms in PD result from the loss of endogenous neurotransmitters. However, it is equally possible that depressive symptoms represent a reaction to the chronic disabling course of PD. By comparing depressive symptoms in PD patients to those in matched patients with other chronic disabling diseases not involving a loss of central monoamines, it may be possible to decide between these alternatives. Thus, depressive symptoms were assessed in 45 patients with PD and 24 disabled controls that did not differ from the PD subjects on a measure of functional disability. Results showed that PD subjects obtained significantly higher total scores on the Beck Depression Inventory (BDI) than controls. PD subjects scored significantly higher than controls on BDI items grouped to reflect cognitive-affective and somatic depressive symptoms. The BDI scores of PD subjects were not reliably related to age, sex, duration of PD, or clinical ratings of PD symptom severity or functional disability. Self-rated disability and the number of recent medical problems were the greatest predictors of depressive symptoms. These findings supported the hypothesis that depressive symptoms in PD may not represent solely a reaction to disability. ( J Geriatr Psychiatry Neurol 1989; 2:3-9).

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Neurology (clinical)

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