Determinants of Cross-Sectional and Longitudinal Health-Related Quality of Life in Memory Clinic Patients Without Dementia-Reference-Cited by-同舟云学术

Determinants of Cross-Sectional and Longitudinal Health-Related Quality of Life in Memory Clinic Patients Without Dementia

Published:2019-10-23 Issue:5 Volume:33 Page:256-264
ISSN:0891-9887
Container-title:Journal of Geriatric Psychiatry and Neurology
language:en
Short-container-title:J Geriatr Psychiatry Neurol

Author:

Banning Leonie C. P.¹^ORCID,Janssen Eveline P. C. J.²³,Hamel Renske E. G.⁴,de Vugt Marjolein¹²,Köhler Sebastian¹,Wolfs Claire A. G.¹²,Oosterveld Saskia M.⁵,Melis Rene J. F.⁵,Olde Rikkert Marcel G. M.⁵,Kessels Roy P. C.⁶⁷,Pijnenburg Yolande A. L.⁸,Koene Ted⁹,van der Flier Wiesje M.⁸¹⁰,Scheltens Philip⁸,Visser Pieter Jelle¹⁸,Verhey Frans R. J.¹²,Aalten Pauline¹,Ramakers Inez H. G. B.¹

Affiliation:

1. Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands

2. Department of Psychiatry and Psychology, Maastricht University Medical Center, Maastricht, the Netherlands

3. Mondriaan Department of Old Age Psychiatry, Heerlen, the Netherlands

4. De Zorggroep, Expertise en Behandelcentrum, the Netherlands

5. Department of Geriatrics & Radboudumc Alzheimer Center, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands

6. Department of Medical Psychology & Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands

7. Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, the Netherlands

8. Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam, VUmc Medical Center, Amsterdam, the Netherlands

9. Department of Medical Psychology and Neuroscience Campus Amsterdam, VUmc Alzheimer Center, VUmc Medical Center, Amsterdam, the Netherlands

10. Department of Epidemiology & Biostatistics, VUmc Medical Center, Amsterdam, the Netherlands

Abstract

Objective: To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 ± 8.6, 64.4% males, Mini-Mental State Examination score 26.9 ± 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 ± 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.

Funder

Alzheimer Nederland

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0891988719882104

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