Fractal analysis of healthy and diseased vasculature in pediatric Moyamoya disease

Abstract

Background and Purpose Fractal dimension is an objective metric for the notion of structural complexity. We sought to investigate differences in structural complexity between healthy and affected territories of cerebral vasculature in moyamoya, as well as associated scalp vasculature and native transdural collaterals in patients with moyamoya by comparing their respective fractal dimensions. Methods Our cohort consisted of 15 transdural collaterals from 12 patients with unilateral anterior circulation moyamoya. Frames of distal arterial vasculature from internal and external carotid angiograms were selected then automatically segmented and also manually annotated by a cerebrovascular surgeon. In the affected hemisphere, the region with transdural collateral supply was compared to the contralateral region. The resulting skeletonized angiograms were analyzed for their fractal dimensions. Results We found the average fractal dimension (Df) of the moyamoya-side ICA was 1.82 with slightly different means for the anteroposterial (AP) and lateral views (mean  =  1.82; mean  =  1.81). The overall mean for healthy cerebral vasculature was also found to be 1.82 (AP: mean  =  1.83; lateral: mean  =  1.81). Mean Df of native transdural collaterals was found to be 1.82 (AP: mean  =  1.83; lateral: mean  =  1.81). The mean Df difference between autosegmented and manually segmented images was 0.013. Conclusion In accordance with the clinical understanding of moyamoya disease, the distal arterial structural complexity is not affected in moyamoya, and is maintained by transdural collaterals formed by vasculogenesis. Autosegmentation of cerebral vasculature is also shown to be accurate when compared to manual segmentation.