Treatment of a ruptured shallow trilobed cerebral aneurysm with the novel saccular endovascular aneurysm lattice (SEAL) device: A case report with one year follow-up

Author:

Pabon Boris1,Torres Victor1,Woodward Keith2,Cardozo Margarita1,Tan Benedict3ORCID,Chaubal Varun3ORCID,Badruddin Aamir4,Wolfe Thomas4,Pereira Edgard4,Jankowitz Brian5,Costalat Vincent6,Altschul David7ORCID,Langerford Claire A8,Zaidat Osama O4

Affiliation:

1. Department of Neurosurgery, Universidad De Antioquia, Medellin, Colombia

2. Department of Neurointerventional Radiology, Covenant Health, Knoxville, TN, USA

3. Department of Neurosciences, St. Vincent Mercy Medical Center, Toledo, OH, USA

4. Galaxy Therapeutics INC, Milpitas, CA, USA

5. Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

6. Department of Neuroradiology, Gui de Chauliac University Hospital of Montpellier, Montpellier, France

7. Department of Neurosurgery, Montefiore Medical Center-Albert Einstein College of Medicine, Bronx, NY, USA

8. MedX CRO, Toledo, OH, USA

Abstract

Intrasaccular flow disruption is a viable alternative to other endovascular treatments for saccular or wide-necked bifurcation intracranial aneurysms; however, wide neck aneurysms with irregular shapes or shallow depth may not be amenable to treatment currently available intrasaccular devices. Here, we present the first ever case report of the novel Saccular Endovascular Aneurysm Lattice Embolization System (SEAL™). The versatile utility of the SEAL™ device is demonstrated in a patient with acute subarachnoid hemorrhage (SAH) from a ruptured, complex, left middle cerebral artery (MCA) trilobed shallow wide-necked bifurcation aneurysm. Deployment and implantation of the SEAL device were technically feasible, safe, and conformed well to the irregular shape of the complex, ruptured aneurysm. Immediate total aneurysm occlusion was observed after implantation. Importantly, 1-year angiographic follow-up demonstrated durable, complete occlusion with no safety concerns. The SEAL device is a promising new novel technology which has the potential to treat very shallow aneurysms with limited height and irregular, multilobulated aneurysms.

Publisher

SAGE Publications

Subject

General Medicine

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