Association of renal surface nodularity with arterial hypertension compared to normotensive patients

Abstract

Background Renal surface nodularity (RSN) is a subclinical biomarker of renal injury and may be associated with arterial hypertension. Purpose To explore the association of RSN with arterial hypertension compared to normotensive patients. Material and Methods A total of 205 inpatients with or without high blood pressure (HBP vs. control group) who underwent abdominal computed tomography (CT) scans were included. Their clinical characteristics included age, sex, HBP course, HBP grade, history of diabetes mellitus (DM), and renal function (estimated glomerular filtration rate [eGFR]). The HBP group included HBP/+DM and HBP/–DM based on the presence or absence of DM. The CT-based RSN grade was scored from 0 to 2 by two radiologists, respectively, where RSN grade 0 indicated smooth renal surface, grade 1 was mild RSN, and grade 2 was marked RSN. Results The inter-rater agreement on RSN was good (Kappa = 0.76). The age-specific rate of RSN grade 1–2 was bigger in the HBP group than in the control group (42.86% [40%–49.22%] vs. 2.18% [0.00%–22.5%]; P = 0.005). RSN grade was associated with HBP course ( P < 0.02). The rates of RSN grade 1–2 and of RSN grade 2 were bigger in the HBP/+DM group than those in the HBP/–DM group (48.84% vs. 37.84%, and 18.61% vs. 1.35%, respectively; all P = 0.001). Neither HBP course nor HBP grade correlated with rate of RSN grade ( P > 0.05). The eGFR was similar among the RSN grades in HBP or between the HBP and control groups ( P > 0.05). Conclusion RSN was associated with HBP compared to normotensive patients.