Comparison of diagnostic quality of 3D ultrashort-echo-time techniques for pulmonary magnetic resonance imaging in free-breathing

Author:

Metz Corona1ORCID,Weng Andreas Max1,Böckle David2ORCID,Heidenreich Julius Frederik1,Slawig Anne3,Benkert Thomas4,Kraus Sabrina2,Köstler Herbert1,Veldhoen Simon1

Affiliation:

1. Department of Diagnostic and Interventional Radiology, University Hospital of Würzburg, Würzburg, Germany

2. Department of Internal Medicine II (Hematology and Oncology), University Hospital of Würzburg, Würzburg, Germany

3. Department for Radiation Medicine, Section Medical Physics, University Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany

4. Application Development, Siemens Healthcare GmbH, Erlangen, Germany

Abstract

BackgroundUltrashort-echo-time (UTE) sequences have been developed to overcome technical limitations of pulmonary magnetic resonance imaging (MRI). Recently, it has been shown that UTE sequences with breath-hold allow rapid image acquisition with sufficient image quality. However, patients with impaired respiration require alternative acquisition strategies while breathing freely.PurposeTo compare the diagnostic performance of free-breathing three-dimensional (3D)-UTE sequences with different trajectories based on pulmonary imaging of immunocompromised patients.Material and MethodsIn a prospective study setting, two 3D-UTE sequences performed in free-breathing and exploiting non-Cartesian trajectories—one using a stack-of-spirals and the other exploiting a radial trajectory—were acquired at 3 T in patients undergoing hematopoietic stem cell transplantation. Two radiologists assessed the images regarding presence of pleural effusions and pulmonary infiltrations. Computed tomography (CT) was used as reference.ResultsA total of 28 datasets, each consisting of free-breathing 3D-UTE MRI with the two sequence techniques and a reference CT scan, were acquired in 20 patients. Interrater agreement was substantial for pulmonary infiltrations using both sequence techniques (κ = 0.77 − 0.78). Regarding pleural effusions, agreement was almost perfect in the stack-of-spirals (κ = 0.81) and moderate in the radial sequence (κ = 0.59). No significant differences in detectability of the assessed pulmonary pathologies were observed between both 3D-UTE sequence techniques ( P > 0.05), and their level of agreement was substantial throughout (κ = 0.62–0.81). Both techniques provided high sensitivities and specificities (79%–100%) for the detection of pulmonary infiltrations and pleural effusions compared to reference CT.ConclusionThe diagnostic performance of the assessed 3D-UTE MRI sequences was similar. Both sequences enable the detection of typical inflammatory lung pathologies.

Funder

Deutsche Forschungsgemeinschaft

Publisher

SAGE Publications

Subject

Radiology, Nuclear Medicine and imaging,General Medicine,Radiological and Ultrasound Technology

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