Effect of Iomeprol on Renal Function Immediately after Abdominal Angiography

Author:

Murakami R.1,Tajima H.1,Kumazaki T.1

Affiliation:

1. Department of Radiology, Nippon Medical School Hospital, Tokyo, Japan.

Abstract

Purpose: To investigate the acute renal effects of 2 osmolality levels of iomeprol in a double-blind, randomized, parallel-group study. Material and Methods: Ten patients received iomeprol 300 mg I/ml, and a further 10 received iomeprol 400 mg I/ml intraarterially at routine abdominal angiography. The mean volume of contrast medium administered was 227.3±59.3 ml in the iomeprol 300 group and 221.5±30.9 ml in the iomeprol 400 group. Results: The urinary minute volume increased immediately after angiography, but tended to return to baseline 120 min after the examination. No significant decrease in creatinine clearance occurred; however, the fraction excretion of sodium increased immediately after angiography. The lysosomal enzyme N-acetyl-β-glucosaminidase and the proximal tubular brush border enzyme γ-glutamyl transferase increased up to 120 min after the procedure. Free water clearance was negative during each study period. No statistical differences in any parameter were evident between these 2 groups. Conclusion: These results suggest that osmotic diuresis and its acute effect on proximal tubular function are induced by the administration of iomeprol, but that these changes are reversible.

Publisher

SAGE Publications

Subject

Radiology, Nuclear Medicine and imaging,General Medicine,Radiological and Ultrasound Technology

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