The benefit of using CT-perfusion imaging for reliable response monitoring in patients with gastrointestinal stromal tumor (GIST) undergoing treatment with novel targeted agents-Reference-Cited by-同舟云学术

The benefit of using CT-perfusion imaging for reliable response monitoring in patients with gastrointestinal stromal tumor (GIST) undergoing treatment with novel targeted agents

Published:2013-09 Issue:7 Volume:54 Page:711-721
ISSN:0284-1851
Container-title:Acta Radiologica
language:en
Short-container-title:Acta Radiol

Author:

Betz Martina¹,Kopp Hans Georg²,Spira Daniel¹,Claussen Claus D¹,Horger Marius¹

Affiliation:

1. Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Tübingen

2. Department of Oncology, Hematology, Rheumatology, Immunolgy, Pulmology, Eberhard-Karls-University, Tübingen, Germany

Abstract

Solely size-based response criteria may be unreliable in patients with gastrointestinal stromal tumors (GIST) treated with tyrosine kinase inhibitors, because they typically underestimate responses to treatment. As GISTs are generally hypervascularized and novel targeted drugs knowingly affect angiogenic signaling pathways, perfusion measurements are expected to deliver important information about their efficacy. This pictorial essay illustrates the benefit of using complementary CT-perfusion-based measurements for more accurate evaluation of response to therapy in GIST.

Publisher

SAGE Publications

Subject

Radiology Nuclear Medicine and imaging,General Medicine,Radiological and Ultrasound Technology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0284185113484642

Reference34 articles.

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2. Gastrointestinal stromal tumour

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