A Case of M-Type Phospholipase A2 Receptor-Associated Membranous Nephropathy With IgG4-Positive Cells Infiltration in the Interstitium-Reference-Cited by-同舟云学术

A Case of M-Type Phospholipase A2 Receptor-Associated Membranous Nephropathy With IgG4-Positive Cells Infiltration in the Interstitium

Published:2022-01 Issue: Volume:15 Page:117954762210786
ISSN:1179-5476
Container-title:Clinical Medicine Insights: Case Reports
language:en
Short-container-title:Clin Med Insights Case Rep

Author:

Ishibuchi Kento¹^ORCID,Iwakura Takamasa¹²,Ema Chiemi²^ORCID,Nakagami Daisuke¹,Uchiyama Yuri¹,Kaneko Mai¹,Fukasawa Hirotaka¹,Matsuyama Takashi²,Yasuda Hideo²,Furuya Ryuichi¹

Affiliation:

1. Renal Division, Department of Internal Medicine, Iwata City Hospital, Iwata, Japan

2. First Department of Internal medicine, Division of Nephrology, Hamamatsu University School of Medicine, Hamamatsu, Japan

Abstract

A 70-year-old man was referred to our department for evaluation of nephrotic syndrome. Renal biopsy revealed membranous nephropathy (MN). Immunohistochemical analysis demonstrated IgG4-positive staining in the glomeruli and interstitial cells. The presence of serum anti-phospholipase A2 receptor (PLA2R) antibody and enhanced staining of PLA2R in the glomeruli was noted. Computed tomography unidentified the extrarenal lesions of IgG4-related disease. He was diagnosed with PLA2R-associated MN possibly complicated with IgG4 related kidney disease (IgG4-RKD). Storiform fibrosis, a typical manifestation of IgG4-RKD, was not apparent. We herein describe a case of serologically and histologically confirmed PLA2R-associated MN with IgG4+ cell infiltration into the interstitium without any signs of IgG4-RD.

Publisher

SAGE Publications

Subject

General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/11795476221078635

Reference29 articles.

1. IgG4-Related Disease

2. Estimation of the number of histological diagnosis for IgG4-related kidney disease referred to the data obtained from the Japan Renal Biopsy Registry (J-RBR) questionnaire and cases reported in the Japanese Society of Nephrology Meetings

3. Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis

4. A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis

5. IgG4-related kidney disease