Treatment randomisation at animal or pen level?-Reference-Cited by-同舟云学术

Treatment randomisation at animal or pen level?

Published:2024-08-19 Issue: Volume: Page:
ISSN:0023-6772
Container-title:Laboratory Animals
language:en
Short-container-title:Lab Anim

Author:

Duchateau Luc¹^ORCID,Dockx Robrecht²,Goethals Klara¹,Vynck Matthijs³,Vangroenweghe Frédéric⁴,Burvenich Christian¹

Affiliation:

1. Biometrics Research Centre, Faculty of Veterinary Medicine, Ghent University, Belgium

2. Department of Applied mathematics, Computer Science and Statistics, Faculty of Sciences, Ghent University, Belgium

3. Department of Morphology, Imaging, Orthopaedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent University, Belgium

4. Elanco Animal Health Benelux – BU Swine & Ruminants, Antwerp, Belgium

Abstract

Random treatment assignment is essential in demonstrating a causal relationship between a treatment and the outcome of interest. Randomisation ensures that animals assigned to different treatment groups do not differ from each other systematically, except for the randomly assigned treatment. The randomisation pattern should also dictate the statistical analysis.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/00236772241247274

Reference7 articles.

1. Dockx R. Meta-analysis of the vaccination effect against Mycoplasma in pigs: The randomization status of the published clinical trials. MSc thesis, Master of Statistical Data Analysis, Ghent University, Belgium, 2023.

2. The unpredictability paradox: review of empirical comparisons of randomised and non-randomised clinical trials

3. Developments in cluster randomized trials andStatistics in Medicine

4. Sample size formulae for intervention studies with the cluster as unit of randomization