Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta)-Reference-Cited by-同舟云学术

Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta)

Published:2021-02-09 Issue:4 Volume:55 Page:363-366
ISSN:0023-6772
Container-title:Laboratory Animals
language:en
Short-container-title:Lab Anim

Author:

Bertrand Henri Georges Michel Justin¹^ORCID,Middleton Joseph Adam²,Baker Stuart Nicolas³,Glover Isabel³,Flecknell Paul Andrew³

Affiliation:

1. University Biomedical Services, University of Cambridge, UK

2. Faculty of Life Science and Medicine, King’s College London, UK

3. Institute of Neuroscience, Newcastle University, UK

Abstract

This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was stimulated, and SEPs were recorded from the motor cortex. The successive administration of three doses of alphaxalone (0.5, 1 and 2 mg/kg) induced an increase of the latency time and a decrease of the amplitude of the SEPs. However, the structure of the waveforms was conserved, and hence alphaxalone might represent a suitable general anaesthetic option in neuroscience research as well as veterinary or human medicine.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0023677221990706

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