Estimation of body surface area in the musk shrew (Suncus murinus): a small animal for testing chemotherapy-induced emesis

Author:

Eiseman Julie L12,Sciullo Michael3,Wang Hong4,Beumer Jan H156,Horn Charles C3789

Affiliation:

1. Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, USA

2. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, USA

3. Biobehavioral Oncology Program, University of Pittsburgh Cancer Institute, Pittsburgh, USA

4. Department of Biostatistics, University of Pittsburgh, Pittsburgh, USA

5. Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, USA

6. Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, USA

7. Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, USA

8. Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, USA

9. Center for Neuroscience, University of Pittsburgh, Pittsburgh, USA

Abstract

Several cancer chemotherapies cause nausea and vomiting, which can be dose-limiting. Musk shrews are used as preclinical models for chemotherapy-induced emesis and for antiemetic effectiveness. Unlike rats and mice, shrews possess a vomiting reflex and demonstrate an emetic profile similar to humans, including acute and delayed phases. As with most animals, dosing of shrews is based on body weight, while translation of such doses to clinically equivalent exposure requires doses based on body surface area. In the current study body surface area in musk shrews was directly assessed to determine the Meeh constant (Km) conversion factor (female = 9.97, male = 9.10), allowing estimation of body surface area based on body weight. These parameters can be used to determine dosing strategies for shrew studies that model human drug exposures, particularly for investigating the emetic liability of cancer chemotherapeutic agents.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

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