A novel rat model for the study of postoperative pancreatic fistula

Author:

Utria Alan F1ORCID,Labadie Kevin P2,Abbasi Arezou2,Gui Xianyong2,Pillarisetty Venu G23,Park James O23,Sham Jonathan G23

Affiliation:

1. University of Iowa Hospitals and Clinics, Iowa City, USA

2. University of Washington, Seattle, USA

3. Fred Hutchinson Cancer Center, Seattle, USA

Abstract

While over the past several decades mortality after pancreatic surgery has decreased to <5%, postoperative morbidity remains remarkably high, ranging from 15% to 65%. The development of a postoperative pancreatic fistula (POPF) is a significant contributor to morbidity in patients undergoing pancreatic surgery. POPF can lead to life-threatening conditions such as intra-abdominal abscess, uncontrolled hemorrhage, sepsis, and death. Rates of POPF have not significantly changed over time, despite the introduction of multiple technical and pharmacologic interventions aimed at their treatment and prevention. Unfortunately, there are few POPF experimental models that have been described in the literature and existing models are unable to reliably reproduce the clinical sequelae of POPF, limiting the development of new methods to prevent and treat POPF. Herein, we describe a new rat experimental model that reliably creates a POPF via transection of the common pancreatic duct.

Funder

Swim Across America

Americas Hepato-Pancreato-Biliary Association

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

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