Cell electrophoresis research directed toward clinical cytodiagnosis.

Author:

Boltz R C,Todd P,Gaines R A,Milito R P,Docherty J J,Thompson C J,Notter M F,Richardson L S,Mortel R

Abstract

The application of cell electrophoresis to cytodiagnosis requires that a scientifically established basis exists for identifying abnormal cells electrophoretically, that research to detect such differences in the cytodiagnostic setting is possible and that a rapid and simple method of cell electrophoresis is adaptable to the clinical setting. Data are presented indicating modifications of electrophoretic mobility due to herpes simplex virus type 1 infection and Rous sarcoma virus transformation of culture cells. A simple apparatus for electrophoretically separating cells on a density gradient and collecting them for subsequent analysis is described, and results of experiments with this apparatus are consistent with those obtained by microscopic electrophoresis. Laser-doppler spectroscopic electrophoresis is suggested as a rapid method adaptable to clinical application.

Publisher

SAGE Publications

Subject

Histology,Anatomy

Cited by 23 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Density Gradient Electrophoresis of Mammalian Cells;Methods of Biochemical Analysis;2006-10-31

2. References;Interfacial Forces in Aqueous Media, Second Edition;2006-05-22

3. Cellular electrophoretic mobility data: A first approach to a database;Electrophoresis;1997

4. Application of an improved density gradient electrophoresis apparatus to the separation of proteins, cells and subcellular organelles;Electrophoresis;1993

5. Separation Physics;Low-Gravity Fluid Dynamics and Transport Phenomena;1990-01-01

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